Viral vectors as vaccine platforms: from immunogenicity to impact

Viral vectors for vaccine applications

Traditional approach of inactivated or live-attenuated vaccine immunization has resulted in impressive success in the reduction and control of infectious disease outbreaks. However, many pathogens remain less amenable to deal with the traditional vaccine strategies, and more appropriate vaccine strategy is in need. Recent discoveries that led to increased understanding of viral molecular biolog...

Viral Vectors for Vaccine Development

Recombinant vectors can be used to deliver antigens and to stimulate immune responses in humans. Viral vectors possess various intrinsic properties which may lend to advantages and disadvantages for usage for a given therapeutic application [reviewed by Larocca and Schlom] [1]. The safety and flexibility of recombinant viral vectors have lead to their usage in gene therapy, virotherapy, and vac...

Plant Viral Vectors as a Tool for Recombinant Vaccine Production

Over the last few years the development of plant viral vectors for protein expression has made rapid and impressive progress. Plant viruses are versatile vectors for production of proteins since they are easy to manipulate, quick to evaluate and offer the possibility of great production yields. They are particularly powerful expression systems for the production of recombinant proteins and pept...

Using DNA and Viral Vectors in Healthy Heterologous Prime-Boost Vaccine Regimens Differential Immunogenicity of Various

Amplicons as vaccine vectors.

HSV-1 amplicon vectors efficiently transduce cultured antigen-presenting cells (APC), including both human and murine dendritic cells as well as primary human chronic lymphocytic leukemia (CLL) B cells. Helper-free amplicons have been shown to be especially well-suited for this purpose, since they do not impair the antigen-presenting functions of these target cells. In vivo, amplicon vectors ha...